20 Best Antidepressant For Pain And Anxiety (2022 Updated)

There are many different types of antidepressant medications available on the market today, each with its own unique set of benefits and side effects. Some of the most commonly prescribed antidepressants for pain and anxiety include selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs).

SSRIs are the most commonly prescribed type of antidepressant medication and are typically very effective at treating both pain and anxiety. Some of the most commonly prescribed SSRIs include fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil).

SNRIs are another type of antidepressant medication that is often prescribed for treating pain and anxiety. SNRIs work by increasing the levels of both serotonin and norepinephrine in the brain, which can help to improve mood and alleviate pain.

Some of the most commonly prescribed SNRIs include duloxetine (Cymbalta) and venlafaxine (Effexor).

TCAs are a older type of antidepressant medication that is not as commonly prescribed as SSRIs or SNRIs, but can still be effective in treating pain and anxiety. TCAs work by inhibiting the reuptake of both serotonin and norepinephrine, which can help to improve mood and alleviate pain.

Some of the most commonly prescribed TCAs include amitriptyline (Elavil) and imipramine (Tofranil).

20 Best Antidepressant For Pain And Anxiety

1. Boiron Sedalia Stress Relief, Quick-Dissolving Tablets – 60 tablets

Boiron Sedalia Stress Relief, Quick-Dissolving Tablets - 60 tablets

  • A homeopathic medicine that works naturally
  • Fast-acting when taken at the onset of symptoms
  • Non-habit forming
  • No side effects, no drug interactions, no contraindications, and no “masking” of symptoms
  • Regulated as a OTC (Over the Counter) drug by the FDA

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Units in Package 60
Indications Uses: Temporarily relieves nervousness, hypersensitivity, irritability and fatigue due to stress. This medicine does not affect alertness.
Directions Adults and Children 12 Years of Age and Older: At the onset of symptoms, dissolve 2 tablets under the tongue 3 times a day until symptoms are relieved. Children Under 12 Years of Age: Ask a doctor.
Ingredients Active Ingredients: (C, K, CK, and X Are Homeopathic Dilutions: See www.boironusa.com for Details): Aconitum Napellus 6C HPUS, Belladonna 6C HPUS (Contains Less than 100000000000000 mg Alkaloids per Dose), Calendula Officinalis 6C HPUS, Chelidonium Majus 6C HPUS, Jequirity 6C HPUS, Viburnum Opulus 6C HPUS. Purpose: Relieves Restlessness, Agitation, The Letters HPUS Indicate That This Ingredient is Officially Included in the Homeopathic Pharmacopoeia of the United States; Relieves Hypersensitivity to Stress, The Letters HPUS Indicate That This Ingredient is Officially Included in the Homeopathic Pharmacopoeia of the United States; Relieves Nervous Fatigue, Hypersensitivity to Noise, The Letters HPUS Indicate That This Ingredient is Officially Included in the Homeopathic Pharmacopoeia of the United States; Relieves Digestive Symptoms Caused by Stress, The Letters HPUS Indicate That This Ingredient is Officially Included in the Homeopathic Pharmacopoeia of the United States; Relieves Uneasiness, The Letters HPUS Indicate That This Ingredient is Officially Included in the Homeopathic Pharmacopoeia of the United States; Relieves Nervousness and Restless Sleep, The Letters HPUS Indicate That This Ingredient is Officially Included in the Homeopathic Pharmacopoeia of the United States. Inactive Ingredients: Croscarmellose Sodium, Lactose, Magnesium Stearate.
Warnings Warnings: Ask a doctor before use in children under 12 years of age. Stop use and ask a doctor if: symptoms persist continuously for more than 2 weeks or worsen. Pregnancy/breast-feeding warning: If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.

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2. Heel Calming, Tablets – 100 tablets

Heel Calming, Tablets - 100 tablets

  • Item Package Length: 3.556cm
  • Item Package Width: 3.81cm
  • Item Package Height: 7.112cm
  • Model Number: BH0028

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Units in Package 100
Directions Adults and Children Above 6 Years: 1 tablet sublingually or dissolved completely in mouth 3 times daily or as directed by a physician. Infants and Children to 6 Years: 1/2 the adult dosage.
Ingredients Each (300 mg) Tablet Contains as Active Ingredients: Chamomilla 2X, Humulus Lupulus 2X, Passiflora Incarnata 2X, Valeriana Officinalis 2X, Veratrum Album 4X, Ignatia Amara 8X, Coffea Cruda 10X, Moschus 10X, Sulphur 12X, Nux Vomica 30X (30 mg each). Inactive Ingredients: Lactose, Magnesium Stearate) (1X=1:10 dilution, 2X=1:100, 3X=1:1000, etc.).
Warnings If symptoms persist or worsen, a physician should be consulted. As with any drug, if you are pregnant or nursing a baby, seek the advice of a health care professional before using this product. Store tightly closed at room temperature. Protect from light and moisture. Keep this and all medicines out of reach of children. Tamper Evident: use this product only if imprinted shrink seal around neck and cap is intact.

3. RediCalm – Clinically-Proven Natural Anxiety Relief Supplement – Non-GMO Vegan

RediCalm - Clinically-Proven Natural Anxiety Relief Supplement - Non-GMO Vegan

  • Ashwagandha.
  • Passion Flower.
  • More than 2 out of 3 participants experienced stress relief within just 30 minutes of taking RediCalm.
  • More than 95% of participants felt an improvement in their overall stress level over the course of 30 days.
  • None of the participants reported any negative side effects.

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Formulation Capsule
Main Purpose Mood & Emotional Support
Type of Diet Vegan
Ingredients L-Theanine/5-HTP
Product Dimensions 1.8 x 1.8 x 3.5 inches; 1.28 ounces

4. Hylands Nerve Tonic, Stress Relief, Quick-Dissolving Tablets – 100 tablets

Hylands Nerve Tonic, Stress Relief, Quick-Dissolving Tablets - 100 tablets

  • 100 Tablets

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Units in Package 100
Indications Uses: Temporarily relieves the symptoms of stress, nervousness, mental anxiousness, irritability, and the inability to concentrate.
Directions Adults & Children 12 Years and Over: Dissolve 1-2 tablets under tongue 3 times per day. Children 6 Years to Under 12 Years: Dissolve 1 tablet under tongue 3 times per day. Sudden Onset: Every 15 minutes for up to 6 doses.
Ingredients Active Ingredients: Calcarea Phosphorica 3X HPUS, Ferrum Phosphoricum 3X HPUS, Kali Phosphoricum 3X HPUS, Natrum Phosphoricum 3X HPUS, Magnesia Phosphorica 3X HPUS. Purpose: Restlessness, Anxiousness, HPUS indicates the active ingredients are in the official Homeopathic Pharmacopoeia of the United States; Unable to Concentrate Thoughts, Nervousness, HPUS indicates the active ingredients are in the official Homeopathic Pharmacopoeia of the United States; Irritability, Mind Sluggish, Nervousness, HPUS indicates the active ingredients are in the official Homeopathic Pharmacopoeia of the United States; Irritability, Anxiousness and Apprehensiveness, HPUS indicates the active ingredients are in the official Homeopathic Pharmacopoeia of the United States; Mental Anxiousness, Very Forgetful, Dullness and Inability to Think Clearly, HPUS indicates the active ingredients are in the official Homeopathic Pharmacopoeia of the United States. Inactive Ingredients: Acacia Gum, Lactose N.F.
Warnings Warnings: Do not use: if imprinted tamper band is broken or missing. As with any drug, ask a doctor before use if pregnant or nursing. Consult a Physician if: symptoms persist for more than 7 days or worsen. Other warnings: Keep this and all medications out of the reach of children. In case of accidental overdose, contact a medical professional or a poison control center immediately. In case of emergency, contact a medical professional or poison control center immediately. Hyland’s may also be contacted for emergency information about our products 24 hours a day, 7 days per week at (800) 624-9659.

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5. Terry Naturally AnxioCalm, Tablets – 45 count

Terry Naturally AnxioCalm, Tablets - 45 count

  • 45 Tablets

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Details
Primary Ingredient Coneflower
Count Per Pack 45
Count 45
Multipack Quantity 1
Body Part Body

6. Genius Stress and Anxiety Relief Supplement w/ Ashwagandha, 30 Capsules Nootropi

Genius Stress and Anxiety Relief Supplement w/ Ashwagandha, 30 Capsules Nootropi

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7. Nature’s Bounty Anxiety & Stress Relief, Tablets – 50 tablets

Nature's Bounty Anxiety & Stress Relief, Tablets - 50 tablets

  • Description
  • Supports Occasional Anxiety & Stress
  • Clinically Studied Ingredients
  • Herbal Health
  • Dietary Supplement

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Allergens Contains milk ingredients.
Rich Ingredients Vegetable Cellulose, Crospovidone, Silica, Vegetable Stearic Acid, Vegetable Magnesium Stearate, Vegetable Glycerin.
Ingredients Vegetable Cellulose, Crospovidone, Silica, Vegetable Stearic Acid, Vegetable Magnesium Stearate, Vegetable Glycerin.
Nutrition Claim Vegetarian
Nutrition Claim Soy Free

8. Anxiety and Stress Relief Supplement

Anxiety and Stress Relief Supplement

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9. Zen Premium Anxiety and Stress Relief Supplement – Natural Herbal Formula

Zen Premium Anxiety and Stress Relief Supplement - Natural Herbal Formula

  • Calmness and relaxation
  • Focus and alertness
  • Positive Moo

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WellPath
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Main Purpose Stress and Anxiety Support
Active Ingredients L-Theanine
Ingredients L-Theanine,Ashwagandha
Formulation Capsule
Number of Pills 60

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10. Dr. Amen GABA Calming Support

Dr. Amen GABA Calming Support

  • MAY BE BENEFICIAL TO ATHLETES – Studies have shown GABA can help increase exercise endurance, promote lean muscle growth, and relieve dull pain
  • Product Dimensions : 2.25 x 2.25 x 3.75 inches; 3.21 Ounces
  • Date First Available : October 30, 2012
  • Best-sellers rank #48,280 in Health & Household (See Top 100 in Health & Household) #1,059 in Blended Vitamin & Mineral Supplements
  • Customer Reviews: 4.3 out of 5 stars 76 ratings

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Serving Size 1 Capsules

11. Liddell Laboratories Go Anxiety + Tension Homeopathic, Oral Spray – 1 oz

Liddell Laboratories Go Anxiety + Tension Homeopathic, Oral Spray - 1 oz

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12. Hylands Sleep Aid, Calms Forte, Tablets – 100 tablets

Hylands Sleep Aid, Calms Forte, Tablets - 100 tablets

  • Natural Relief
  • Non-Habit Forming
  • Helps To Relieve Stress To Help You Sleep
  • Safe & Effective Relief of: Occasional Sleeplessness and Restless Sleep Stress
  • Safe, gentle and effective

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Units in Package 100
Indications Uses: Temporarily relieves the symptoms of occasional sleeplessness and restlessness with accompanying stress, anxiousness, nervousness and irritability.
Directions Adults & Children 12 Years and Over: As a relaxant: swallow 1-2 tablets with water as needed three times daily. For occasional sleeplessness: 1-3 tablets 1/2 to 1 hour before retiring. Children 6-12 Years: As a relaxant: swallow 1 tablet with water as needed three times daily. For Occasional Sleeplessness: 1-2 tablets 1/2 to 1 hour before retiring.
Ingredients Active Ingredients: Avena Sativa 4X HPUS, Calcarea Phosphorica 3X HPUS, Chamomilla 4X HPUS, Ferrum Phosphoricum 3X HPUS, Humulus Lupulus 4X HPUS, Kali Phosphoricum 3X HPUS, Magnesia Phosphorica 3X HPUS, Natrum Phosphoricum 3X HPUS, Passiflora 4X HPUS. Purpose: Stress, Nervousness, HPUS Indicates the Active Ingredients Are in the Official Homeopathic Pharmacopoeia of the United States; Restlessness, HPUS Indicates the Active Ingredients Are in the Official Homeopathic Pharmacopoeia of the United States; Nervous Irritability, HPUS Indicates the Active Ingredients Are in the Official Homeopathic Pharmacopoeia of the United States; Nervousness, HPUS indicates the active ingredients are in the official Homeopathic Pharmacopoeia of the United States; Occasional Sleeplessness, HPUS Indicates the Active Ingredients Are in the Official Homeopathic Pharmacopoeia of the United States; Irritability, HPUS Indicates the Active Ingredients Are in the Official Homeopathic Pharmacopoeia of the United States; Mental Anxiousness, HPUS Indicates the Active Ingredients Are in the Official Homeopathic Pharmacopoeia of the United States; Anxiousness, HPUS Indicates the Active Ingredients Are in the Official Homeopathic Pharmacopoeia of the United States; Restless Sleep from Exhaustion, HPUS Indicates the Active Ingredients Are in the Official Homeopathic Pharmacopoeia of the United States. Inactive Ingredients: Lactose, Magnesium Stearate, Microcrystalline Cellulose, Starch (Corn and Tapioca).
Warnings Warnings: Do not use: if imprinted tamper band is broken or missing. Pregnancy/breast-feeding warning: As with any drug, ask a doctor before use if pregnant or breast-feeding. Other warnings: Consult a physician if symptoms persist for more than 7 days. Keep this and all medications out of the reach of children. In case of accidental overdose, contact a medical professional or Poison Control Center immediately. In case of emergency, contact a medical professional or Poison Control Center immediately. Hyland’s may also be contacted for emergency information about our products 24 hours a day, 7 days per week at (800)624-9659.

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13. Priority One – Anxiety Balance – 90 Vegetarian Capsules

Priority One - Anxiety Balance - 90 Vegetarian Capsules

  • 90 Capsules

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Ingredients Amount
Thiamine HCl (Vitamin B1) 25 mg
Niacin (As Niacinamide) 25 mg NE
Magnesium (as Oxide Aspartate) 5 mg
Gamma Amino Butyric Acid (GABA) 100 mg

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14. Hylands Calms Forte, Tablets – 100 tablets

Hylands Calms Forte, Tablets - 100 tablets

  • Temporary symptomatic relief of Nervous Tension and Occasional Sleeplessness
  • Natural Soothing formula eases tension and promotes sleep naturally to help you wake-up feeling refreshed
  • Homeopathic natural stress relief medicine that is not habit forming and is safe and gentle and helps you sleep at night
  • Just take 1 to 2 tablets with water as needed three times daily to help relieve symptoms of nervous tension and occasional sleeplessness

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Best Price Nutrition

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Units in Package 100
Indications Uses: Temporarily relieves the symptoms of simple nervous tension and occasional sleeplessness.
Directions Adults: As a Relaxant: 1 to 2 tablets with water as needed three times daily. Adults: For Occasional Sleeplessness: 1 to 3 tablets 1/2 to 1 hour before retiring. Children 6-12 Years: 1/2 adult dose.
Ingredients Active Ingredients: Avena Sativa HPUS (1X) Double Strength, Chamomilla HPUS (2X), Humulus Lupulus HPUS (1X) Double Strength, Passiflora HPUS (1X) Triple Strength, Biochemic Phosphates, Calc. Phos HPUS (3X), Ferrum Phos HPUS (3X), Kali Phos HPUX (3X), Mag. Phos HPUS (3X), Nat. Phos HPUS (3X). Purpose: Stress, Nervousness. Nervous Irritability. Occasional Sleeplessness. Restless Sleep from Exhaustion. Enhances Cellular Function. Inactive Ingredients: Lactose NF, Starch (Corn and Tapioca), Vegetable Magnesium Stearate.
Warnings Warnings: Other warnings: Ask a doctor before use if pregnant or nursing. Consult a physician if symptoms persist for more than 7 days or worsen. Keep out of the reach of children. Do not use if imprinted tamper band is broken or missing. In case of accidental overdose, contact a poison control center immediately. In case of emergency, Hyland’s may be contacted 24 hours a day, 7 days a week at 800/624-9659.

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15. Source Naturals Theanine Serene with Relora, Tablets – 60 count

Source Naturals Theanine Serene with Relora, Tablets - 60 count

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Rich Ingredients sorbitol, stearic acid, modified cellulose gum, hydroxypropyl cellulose, magnesium stearate, and silica.
Ingredients sorbitol, stearic acid, modified cellulose gum, hydroxypropyl cellulose, magnesium stearate, and silica.
Nutrition Claim Vegetarian
Nutrition Claim Sugar Free
Nutrition Claim Artificial Color Free
Nutrition Claim Gluten Free
Nutrition Claim For Cognitive/Smart

16. Natrol Stress & Anxiety Formula, Mood & Stress, Capsules – 90 capsules

Natrol Stress & Anxiety Formula, Mood & Stress, Capsules - 90 capsules

  • Helps reduce stress
  • Helps reduce anxiety
  • Promotes relaxation
  • Enhances mental focus and clarity
  • Supports positive mood

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Details
Units in Package 90
Directions Directions: Take 4 capsules, one time daily, with a meal. Store in a cool, dry place. Lift.
Ingredients Other Ingredients: Cellulose, Gelatin, Magnesium Stearate, Mono and Diglycerides, Hypromellose.
Warnings Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating. Keep out of reach of children.
Nutrition Facts
Serving Size 4 capsules
Servings Per Container About 22

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17. Herb Pharm Anxiety Soother – 1 fl oz dropper

Herb Pharm Anxiety Soother - 1 fl oz dropper

  • 1 oz

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Rich Ingredients certified organic cane alcohol (66-76%), distilled water & certified organic vegetable glycerin.
Ingredients certified organic cane alcohol (66-76%), distilled water & certified organic vegetable glycerin.
Nutrition Claim Gluten Free

18. Naturalcare Anxiety Relief, Sublingual Tablets – 120 tablets

Naturalcare Anxiety Relief, Sublingual Tablets - 120 tablets

  • For Symptoms of Anxiety and Stress
  • Non-Addictive
  • No Side-Effects
  • No Function Impairment
  • Homeopathic Formula

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Azure Standard
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Units in Package 120
Indications For the symptomatic relief of occasional minor anxiety, fear, anguish, stress, and worry associated with the ups and downs of everyday life.
Directions Adults and Children Ages 12 and Older: Dissolve 1-2 tablets under tongue 3 times daily. If experiencing anxious, panicky feelings, safely take 1-2 tablets every 20-30 minutes until symptoms improve. Children 2-12 Years of Age: Dissolve 1 tablet 3 times daily, or as directed by a doctor. For best results, do not eat 10 minutes before and after dosage.
Ingredients Active Ingredients: Aconitum Napellus 9X; Argentum Nitricum 8X; Arsenicum Album 9X; Aurum Metallicum 8X; Gelsemium Sempervirens 8X, 30X; Hyoscyamus Niger 6X, 12X; Ignatia Amara 6X, 12X; Kali Carbonicum 12X, 30X; Moschus 12X; Natrum Muriaticum 6X, 12X, 30X; and Piper Methysticum 3X, 6X, 12X, 30X. Other Ingredients: Dextrose.
Warnings Do not use if safety seal is broken or missing. If symptoms persist for over 30 days, or become more severe, ask a doctor. If pregnant or nursing, ask a doctor before use. Keep out of the reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

19. Natrol Stress & Anxiety Day & Night Tablets, 20 Tablets

Natrol Stress & Anxiety Day & Night Tablets, 20 Tablets

  • 20 Ct

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Units in Package 2
Directions Day: Directions: Take 1 white tablet, one or two times daily, with food. Do not exceed recommended dose. Night: Directions: Take 1 tan tablet before bedtime. Store in a cool, dry place.
Ingredients Day: Other Ingredients: Dibasic Calcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Hypromellose, Silicon Dioxide, Magnesium Stearate, Cellulose Gum, Methylcellulose, Glycerin. Night: Other Ingredients: Microcrystalline Cellulose, Maltodextrin, Stearic Acid, Silicon Dioxide, Cellulose Gum, Hypromellose, Methylcellulose, Magnesium Stearate, Gum Arabic, Glycerin, Ethylcellulose.
Warnings Contains: soy. Day: Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, or are taking prescription drugs, including drugs for depression, migraines, Parkinson’s disease or psychiatric disorders. Do not use with other supplements containing L-tryptophan or 5-HTP. Do not use if you are pregnant, lactating or under the age of 18 years. Tamper evident packaging. Night: Warning: If you are under medical supervision or using any tranquilizers or sedatives, seek the advice of your healthcare professional prior to using. Consult your healthcare professional before using if you have an autoimmune condition, depressive disorder or are pregnant or lactating. Not for use by children under 12 years of age. Do not take when operating machinery or driving a vehicle. Keep out of reach of children.
Serving Size 1 tablet

20. Pileje Lactibiane Melioran (Support in Depression and Anxiety) 90 Tabs

Pileje Lactibiane Melioran (Support in Depression and Anxiety) 90 Tabs

  • Help the body adapt to emotional stress;.
  • Helps stimulate the nervous system;.
  • Improves mood, including mood.

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Conclusion

While there are many possible causes of pain and anxiety, antidepressants are often used as a treatment for both conditions. Antidepressants work by affecting the levels of certain chemicals in the brain, which can help to improve mood and relieve pain.

There are a variety of different types of antidepressants, and the most effective type for each individual may vary. Some common side effects of antidepressants include nausea, headache, dry mouth, and sexual dysfunction.

It is important to discuss any potential side effects with a healthcare provider before starting antidepressant medication.

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