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Best Over Counter Pain Reliever (2024 Update)

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If you’re looking for a pain reliever that you can easily purchase without a prescription, an over-the-counter (OTC) pain reliever is your best option. There are several types to choose from, ranging from nonsteroidal anti-inflammatory drugs (NSAIDs) to acetaminophen. But before you buy any OTC pain reliever, there are certain factors you should consider to ensure that you choose the best one for you.

One of the essential factors to consider is the type of pain you are experiencing. You should choose an OTC pain reliever that's specifically designed to relieve your type of pain. If you're experiencing inflammation, an NSAID may work best. If you have a headache, choosing an OTC pain reliever that targets headaches specifically would be more beneficial.

Another factor to consider is any pre-existing medical conditions or any medications you are currently taking. This may affect which OTC pain reliever is safe for you to use. It’s always best to consult a healthcare provider before taking any new medication.

Do you often find yourself searching for the best OTC pain reliever? Have you tried different kinds but are still looking for the perfect one for you? Do you experience side effects with certain pain relievers that have made you hesitant to try others? If so, keep reading, and you might discover the perfect pain reliever for you.

10 Best Over Counter Pain Reliever

# Product Image Product Name Product Notes Check Price
1
Relieving pain and aiding in sleep at night with 200mg strength and a count of 80.
2
This product is ideal for relieving pain and aiding sleep.
3
The product is ideal for fast-acting pain relief for arthritis, lower back pain, knee pain, and neck pain.
4
It is ideal for those seeking pain relief and a sleep aid in one product.
5
This product is ideal for relieving pain, including headaches, muscle and joint pain, menstrual pain, and back pain.
6
This product is ideal for providing relief from menstrual symptoms, including pain, while on the go.
7
This product is ideal for pain relief and reducing fever.
8
Ideal for pain relief in adults suffering from headaches, backaches, menstrual cramps and joint pain.
9
The product is ideal for relieving pain and discomfort, and comes in a pack of 3.
10
It is an over-the-counter pain reliever and fever reducer that contains naproxen sodium as its active ingredient.
Relieving pain and aiding in sleep at night with 200mg strength and a count of 80.
This product is ideal for relieving pain and aiding sleep.
The product is ideal for fast-acting pain relief for arthritis, lower back pain, knee pain, and neck pain.
It is ideal for those seeking pain relief and a sleep aid in one product.
This product is ideal for relieving pain, including headaches, muscle and joint pain, menstrual pain, and back pain.
This product is ideal for providing relief from menstrual symptoms, including pain, while on the go.
This product is ideal for pain relief and reducing fever.
Ideal for pain relief in adults suffering from headaches, backaches, menstrual cramps and joint pain.
The product is ideal for relieving pain and discomfort, and comes in a pack of 3.
It is an over-the-counter pain reliever and fever reducer that contains naproxen sodium as its active ingredient.

1. Advil Pm Liqui-Gels, Pain Reliever/nighttime Sleep Aid- 200mg, 80 Count

Introducing Advil PM Liqui-Gels, a powerful pain reliever and nighttime sleep aid that comes in a convenient bottle of 80 liquid-filled capsules. Each capsule contains a combination of ibuprofen and diphenhydramine HCL, which effectively alleviate pain and promote better sleep.

This pain medicine is specially formulated to relieve occasional sleeplessness associated with minor aches and pains such as headaches, arthritis, and back pain. It is suitable for adults and children 12 years and older who may be experiencing discomfort and difficulty sleeping.

To use this pain reliever and sleep aid, simply take two capsules at bedtime as needed. The liquid-filled capsules are easy to swallow and work quickly to provide relief.

In addition to its pain-relieving and sleep-promoting benefits, Advil PM Liqui-Gels also helps reduce environmental waste. By 2022, the product's new packaging will feature 20% less plastic, which translates to nearly 500,000 pounds of plastic saved from landfills.

This product is eligible for HSA and FSA reimbursement, making it a smart choice for those looking to manage their healthcare expenses. Experience the relief and restful sleep you deserve with Advil PM Liqui-Gels.

2. Fast-Acting Stopain Max Strength Pain Relief Gel

The Stopain Maximum Strength Pain Relieving Roll-On is a powerful solution for those who suffer from joint, muscle, and arthritis aches and pains. Unlike other products that simply dull the pain, Stopain's maximum strength formula is designed to stop the pain fast.

This menthol-based topical analgesic provides immediate penetrating relief upon application and is free from dyes, fragrances, and preservatives. It works on contact and is non-staining, non-greasy, non-irritating, and non-allergenic.

For over 30 years, Stopain's proven tested integrity has provided millions of customers with relief from aching muscles and joints. Made in the USA with the highest quality ingredients, this product is trusted by healthcare professionals and pharmacists alike.

Stopain's extra strength formula is perfect for those who need a little extra help with their pain. It contains MSM and Glucosamine, which support joint flexibility and mobility. This product is easy to use and does not contain NSAIDs, making it a safer alternative for those who cannot take traditional pain medications.

Whether you're dealing with a sprain, strain, backache, shoulder, knees, hands, wrist, or feet pain, Stopain Maximum Strength Pain Relieving Roll-On is the perfect solution. There is no need for a patch, liniment, cream, hot balm, ointment, or ice.

3. Sleep-Ease Pain Relief Capsules

The Advil PM Liqui-Gels Pain Reliever and Nighttime Sleep Aid is a must-have for anyone who experiences occasional sleeplessness related to minor aches and pains. This product comes in two bottles, each containing 80 liquid-filled capsules that are easy to swallow. The pain medicine contains Ibuprofen, which is great for pain relief, and Diphenhydramine HCL, which is an effective sleep aid.

The Ibuprofen PM pain medicine in Advil PM Liqui-Gels helps relieve occasional sleeplessness related to minor aches and pains. It is a potent pain reliever that rushes liquid relief right where it hurts, providing quick relief throughout the night. This nighttime pain reliever is specially designed to help you fall asleep and stay asleep, ensuring you wake up feeling refreshed and rejuvenated.

The Advil PM Liqui-Gels Pain Reliever and Nighttime Sleep Aid is an excellent pain PM medicine for headache relief, minor arthritis pain relief, back pain medicine, and sleep aid for adults and children 12 years and older. Its dual-purpose formulation makes it an ideal choice for people who want to relieve their pain and get a good night's sleep.

To use, simply take two Advil pain reliever caplets at bedtime for occasional sleeplessness related to minor aches and pains. The product is easy to swallow and starts working quickly, so you can fall asleep faster and stay asleep longer. It is a safe and effective way to manage your pain and sleep issues.

4. Extra Strength Pain And Fever Relief Caplets

Rite Aid Extra Strength Acetaminophen caplets are a reliable solution for temporary relief from fevers and minor headaches or migraines. Additionally, these caplets offer relief from muscular and body aches, as well as pains that are often associated with arthritis and/or joint pain. This pain reliever and fever reducer is designed to provide effective pain relief with extra strength.

Rite Aid’s Extra Strength Acetaminophen 500mg caplets can be compared to the active ingredient in Extra Strength Tylenol. These caplets are designed to offer all the benefits of an effective pain reliever, making them a great choice for those seeking relief from pain.

The easy-to-swallow caplets are shaped in a way that makes them easier to consume. This makes Rite Aid Acetaminophen ideal for use at home or on the go, providing menstrual pain relief, joint/muscle pain relief, and migraine relief, among other types of pain.

These pain relief pills contain 500 mg of pain-relieving and fever-reducing acetaminophen without any aspirin. This aspirin-free muscle, joint, or back pain relief medicine is formulated for those with aspirin allergies or sensitivities.

Rite Aid has been a trusted brand since 1962, and the company continues to prioritize the health and wellness of its customers by providing the best products, services, and advice. Rite Aid hopes to be your go-to solution for everyday health and wellness needs.

5. Pain-Free Periods On The Go!

The Midol Complete On the Go Menstrual Pain Relief Caplets with Acetaminophen, Caffeine and Pyrilamine Maleate is the perfect solution for women who experience menstrual pain, backache, muscle ache, headache, fatigue, bloating, and water weight gain. This product comes in 25 count pouches with a total of 50 caplets for effective menstrual symptom relief.

The caplets contain acetaminophen, which is a highly effective pain reliever that provides relief from period pain, as well as backache, muscle ache, and headache. The formula also includes caffeine and pyrilamine maleate, which work together to reduce fatigue and alleviate symptoms such as bloating and water weight gain.

For women who are constantly on the go, this product is available in convenient on the go pouches that each contain two easy to take caplets. This means that you can take them with you wherever you go, and you won't have to worry about missing a dose when you need it the most.

To use this product, simply take two caplets with water and repeat every six hours as needed. However, it is important not to take more than six caplets a day to avoid any potential side effects.

6. Arthritis Relief With Aleve Easy Open Cap.

The Aleve Easy Open Arthritis Cap is a highly commended product by the Arthritis Foundation for its ease of use. This cap has been designed specifically to cater to individuals with arthritis, making it easier for them to open the bottle and take the medication. The cap has been crafted with a smooth texture, ensuring a comfortable grip, and it can be easily twisted open with minimal effort.

The Aleve Easy Open Arthritis Cap contains a powerful pain relief formula that can provide relief for up to 12 hours with just one tablet. This makes it a convenient and effective option for individuals who require long-lasting relief from minor arthritis pain. However, it is important to note that this cap is not child-resistant, so it should be kept out of reach of children.

ALEVE is a trusted brand that has gained popularity among orthopedic doctors as the number one recommended brand for minor arthritis pain. The brand has also proven to be more effective than Tylenol 8hr when it comes to tough pain relief, as evidenced by menstrual and dental pain studies.

7. Double Relief Bundle: Advil Liqui-Gels & Pm

The Advil Liqui-Gels Pain Reliever and Fever Reducer Liquid Filled Capsules, along with 2 Advil PM Caplets, provide a comprehensive solution for pain relief and fever reduction. With 200 ibuprofen liqui-gels in one package, this product offers fast and strong pain relief targeted right where you need it most. Compared to Tylenol Rapid Release Gels, Advil ibuprofen liqui-gels provide superior pain relief.

This product is perfect for those who suffer from various types of pain, including back pain, joint pain, menstrual pain, headache pain, and muscle aches. It also provides relief from aches and pains caused by the common cold.

Advil ibuprofen liqui-gels are designed for fast absorption, making them an effective non-aspirin, nonsteroidal anti-inflammatory pain reliever. With these liqui-gels, you can experience quick and effective relief from pain.

This product is suitable for both adults and children 12 years and older. It is also a fever reducer for adults, making it a versatile solution for those experiencing fever along with pain.

8. Vanquish Extra Strength Pain Reliever Caplets-100 Ct. (Pack Of 3)

When it comes to alleviating minor pain, this product is a reliable go-to for a variety of conditions. Whether you're dealing with a headache, backache, menstrual cramps, arthritis, colds and flu, or muscle aches, this solution can provide temporary relief. Its formula is designed to tackle a range of discomforts, making it a versatile option for anyone seeking relief from mild pain. With this product at your disposal, you can experience the comfort and ease you need to get through your day with greater ease. So why suffer when you can turn to this trusted solution for temporary pain relief?

9. Goodsense Naproxen Sodium Tablets 220 Mg, Pain Reliever And Fever Reducer (Nsaid), 400 Count

GoodSense Naproxen Sodium Tablets 220 mg is a trusted pain reliever and fever reducer that contains the active ingredient naproxen sodium 220 mg, a nonsteroidal anti-inflammatory drug (NSAID). It is equivalent to the active ingredient found in Aleve Caplets.

One of the standout features of this product is its strength to last up to 12 hours. This means that it provides long-lasting pain relief and fever reduction, helping you get through your day without having to constantly take medication.

GoodSense Naproxen Sodium Tablets 220 mg can provide temporary relief for a variety of minor aches and pains, including those associated with arthritis, muscular aches, backaches, menstrual cramps, headaches, toothaches, and the common cold. It can also temporarily reduce fever.

This pain reliever and fever reducer is suitable for adults and children aged 12 years and over, making it a versatile and convenient choice for families.

The tablets are capsule-shaped and easy to swallow. They are also gluten-free, making them a safe option for those with gluten sensitivities.

Best Over Counter Pain Reliever FAQs

What is the best over-the-counter pain reliever for arthritis pain?

There are several over-the-counter pain relievers available for arthritis pain, but the best one would depend on the individual's specific needs and preferences. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen are commonly used to relieve arthritis pain and inflammation. Acetaminophen is another option for pain relief, but it does not have anti-inflammatory properties. Some people find relief with topical pain relievers such as creams or gels containing menthol or capsaicin. It is important to speak with a healthcare professional before starting any new medication, especially if there are pre-existing medical conditions or allergies. They can provide personalized recommendations and guidance on the best over-the-counter pain reliever for arthritis pain based on the individual's health history and current medications.

What is the best over-the-counter pain reliever for back pain?

There are several over-the-counter pain relievers that can help alleviate back pain. The most commonly used ones include acetaminophen, ibuprofen, and naproxen. Acetaminophen is typically recommended as a first-line treatment for mild to moderate back pain. It works by blocking the production of prostaglandins, which are chemicals that cause pain and inflammation in the body. Ibuprofen and naproxen are nonsteroidal anti-inflammatory drugs (NSAIDs) that can also provide relief for back pain. They work by reducing inflammation and swelling in the affected area. It is important to follow the recommended dosage and duration of use for any over-the-counter pain reliever, as excessive use can lead to serious side effects such as liver damage or gastrointestinal bleeding. If symptoms persist or worsen, it is recommended to seek medical attention from a healthcare professional.

What is the best over-the-counter pain reliever for headaches?

There are several over-the-counter pain relievers available for headaches, and the best one for you may depend on your specific symptoms and medical history. However, some of the most commonly used pain relievers for headaches include acetaminophen (Tylenol), ibuprofen (Advil, Motrin), and aspirin.

Acetaminophen works by blocking pain signals in the brain and is generally considered safe for most people. Ibuprofen and aspirin are nonsteroidal anti-inflammatory drugs (NSAIDs) that work by reducing inflammation in the body.

It is important to follow the recommended dosages and instructions on the label of these pain relievers, as taking too much can have harmful side effects. Additionally, if your headaches persist or are severe, it is important to talk to your healthcare provider to rule out any underlying medical conditions and discuss appropriate treatment options.

What is the best over-the-counter pain reliever for menstrual cramps?

The best over-the-counter pain reliever for menstrual cramps varies from person to person since different people may have different pain thresholds and experiences. However, some of the most commonly used over-the-counter pain relievers for menstrual cramps include aspirin, ibuprofen, and naproxen. These drugs are nonsteroidal anti-inflammatory drugs (NSAIDs) that work by reducing the production of prostaglandins, which cause inflammation and pain. It is advisable to take these pain relievers at the first signs of menstrual cramps and to follow the recommended dosage on the label. It is also important to note that some people may experience side effects such as stomach upset or heartburn, so it is best to consult with a healthcare provider if you have any concerns or if you have underlying medical conditions. Additionally, some people find that applying heat to the lower abdomen or taking warm baths can also help alleviate menstrual cramps.

What is the best over-the-counter pain reliever for nerve pain?

There are several over-the-counter pain relievers available for nerve pain, but the effectiveness may vary from person to person. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen can help relieve mild to moderate nerve pain. Acetaminophen is another option that can help reduce pain but does not have anti-inflammatory properties. However, it is important to note that these medications may not be effective for severe nerve pain.

Another option for nerve pain relief is topical creams or ointments that contain capsaicin or lidocaine. Capsaicin works by decreasing the sensitivity of nerve endings, while lidocaine numbs the area to reduce pain. These topical treatments can be applied directly to the affected area for targeted pain relief.

It is important to consult with a healthcare professional before taking any over-the-counter pain relievers, especially if you have any underlying medical conditions or are taking other medications. They can help determine the best course of treatment for your specific needs.

What is the best over-the-counter pain reliever for toothache?

There are several over-the-counter pain relievers that can provide temporary relief for toothache pain. The most commonly used are acetaminophen (such as Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (such as Advil or Motrin). These medications can help reduce pain, inflammation, and fever. However, it's important to always follow the recommended dosage and not exceed the maximum daily limit, as this can lead to potential side effects or complications.

It's also important to note that while over-the-counter pain relievers can provide temporary relief, they do not address the underlying cause of the toothache. If the pain persists or is accompanied by other symptoms such as swelling, fever, or difficulty breathing, it's important to see a dentist as soon as possible. Your dentist can diagnose the underlying cause of the toothache and provide appropriate treatment to address the issue.

What is the fastest-working over-the-counter pain reliever for acute pain?

The fastest-working over-the-counter pain reliever for acute pain is generally considered to be ibuprofen. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing inflammation in the body. It is commonly used to relieve pain from conditions such as headaches, menstrual cramps, and muscle aches.

Ibuprofen is available in various forms, including tablets, capsules, and liquids. It is important to follow the recommended dosages and precautions when taking ibuprofen, as it can have side effects such as stomach upset and increased risk of bleeding.

However, it is important to note that everyone's body reacts differently to medications. If ibuprofen does not provide sufficient pain relief, it may be necessary to try a different over-the-counter pain reliever or consult a healthcare professional for further advice.

What is the most effective over-the-counter pain reliever for joint pain?

When it comes to over-the-counter pain relievers for joint pain, there are a few options to consider. The most commonly used pain relievers for joint pain are nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen. These medications work by reducing inflammation in the joints, which can help alleviate pain. Acetaminophen is another option that can be effective for mild to moderate joint pain. Unlike NSAIDs, acetaminophen does not reduce inflammation but instead works by blocking pain signals to the brain. It is important to note that overuse of NSAIDs can lead to side effects such as stomach ulcers and kidney damage, so it is best to use them only as directed and under the guidance of a healthcare provider. Additionally, it is important to consider other non-pharmacological treatments such as exercise, physical therapy, and hot/cold therapy to manage joint pain. If your joint pain is severe or persistent, it is important to seek medical advice from a healthcare professional.

What is the safest over-the-counter pain reliever for long-term use?

When it comes to over-the-counter pain relievers, there are many options available. However, not all of them are suitable for long-term use. The safest over-the-counter pain reliever for long-term use is generally considered to be acetaminophen. It is a non-steroidal anti-inflammatory drug (NSAID) that is effective in relieving mild to moderate pain. Unlike other NSAIDs such as ibuprofen and naproxen, acetaminophen does not have anti-inflammatory properties, which makes it less likely to cause stomach irritation and ulcers.

However, it is important to note that even though acetaminophen is generally considered safe, it can still cause liver damage if taken in large doses. Therefore, it is important to follow the recommended dosage and not exceed the maximum daily dose of 4,000 milligrams. If you are unsure about which pain reliever is best for you, it is always best to consult with your healthcare provider.

What is the strongest over-the-counter pain reliever for muscle pain?

The strongest over-the-counter pain reliever for muscle pain is generally considered to be either ibuprofen or naproxen. Both of these medications are classified as nonsteroidal anti-inflammatory drugs (NSAIDs) and work by reducing inflammation and pain throughout the body. Ibuprofen is sold under various brand names such as Advil or Motrin, while naproxen is sold under the brand name Aleve. It is important to note that while these medications are effective in relieving muscle pain, they also come with potential side effects such as stomach ulcers, kidney damage, and high blood pressure. It is always recommended to follow the recommended dosage and to talk to a healthcare professional before taking any medication, especially if you have any pre-existing medical conditions or are taking other medications.

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