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Best Cold Sore Medicine Prescription (2024 Update)

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If you're looking for relief from the discomfort and embarrassment of cold sores, you're not alone. Cold sores are a common affliction, and many people turn to prescription medicines to help shorten the duration and severity of outbreaks. But how do you know which is the best cold sore medicine for you?

Before buying any cold sore medication, it's important to consider a few factors. First, what is the active ingredient? Different medications use different antiviral agents to fight cold sores, and some may be more effective than others for your particular case. Also, how soon after symptoms appear do you need to start taking the medication? Some medications are most effective when taken at the very first sign of a cold sore, so timing may be critical. Finally, how often do you experience outbreaks? If they are infrequent, you may want to consider a medication with a longer course of treatment rather than a short-term solution.

If you're still unsure which cold sore medication to choose, ask yourself these questions: Have you tried other treatments in the past? Do you have any allergies or sensitivities to certain ingredients? Are you looking for a prescription medication or an over-the-counter solution? By taking the time to research your options and evaluate your needs, you can find the best cold sore medicine for you and give yourself some much-needed relief.

10 Best Cold Sore Medicine Prescription

# Product Image Product Name Product Notes Check Price
1
This product is ideal for treating fever blisters and reducing the time it takes for them to heal.
2
It is ideal for soothing itching and burning associated with cold sores, while providing discreet coverage.
3
The product is ideal for providing fast relief for cold sores, fevers, rashes, red bumps, and healing delicate skin.
4
The product is ideal for helping against outbreaks and cold sores with quick symptom relief and no side effects.
5
It is ideal for treating cold sores, canker sores, lip blisters, and oral herpes using high irradiance red light therapy.
6
The product is ideal for treating symptoms and promoting faster healing of cold sores or fever blisters.
7
It is ideal for treating cold sores or fever blisters.
8
It is an ideal product for individuals suffering from herpes, providing natural and gentle relief in a tube.
9
Lip balm designed to treat cold sores and promote healing.
10
It is ideal for treating cold sores and fever blisters.
This product is ideal for treating fever blisters and reducing the time it takes for them to heal.
It is ideal for soothing itching and burning associated with cold sores, while providing discreet coverage.
The product is ideal for providing fast relief for cold sores, fevers, rashes, red bumps, and healing delicate skin.
The product is ideal for helping against outbreaks and cold sores with quick symptom relief and no side effects.
It is ideal for treating cold sores, canker sores, lip blisters, and oral herpes using high irradiance red light therapy.
The product is ideal for treating symptoms and promoting faster healing of cold sores or fever blisters.
It is ideal for treating cold sores or fever blisters.
It is an ideal product for individuals suffering from herpes, providing natural and gentle relief in a tube.
Lip balm designed to treat cold sores and promote healing.
It is ideal for treating cold sores and fever blisters.

1. Quickclear Cold Sore Treatment – Twin Pack

Introducing the Number 1 Cold Sore Brand, Abreva Cream, which comes in two 0.07 oz tubes for a total of 0.14 oz of cold sore treatment. With its powerful formula containing 10 percent docosanol, this fever blister cream can heal cold sores in just 2.5 days (1).

Abreva Cream is scientifically designed to penetrate deep into the skin, tackling cold sores at their source (1, 2, 3). Its fast-acting formula is clinically proven to shorten the duration of cold sore symptoms, including tingling, pain, burning, and itching (1).

This portable cold sore cream comes in a convenient tube that can easily fit in your purse or pocket, making it an ideal on-the-go treatment option. Abreva Cream is also the number 1 dermatologist-recommended cold sore treatment, offering a non-prescription solution to shorten the healing time of cold sores (1).

In addition to its effectiveness, Abreva Cream is HSA and FSA eligible, making it a convenient and affordable treatment option. Say goodbye to the discomfort and embarrassment of cold sores with Abreva Cream, the fast-acting, clinically proven solution for cold sore relief.

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2. Cold Sore Duo 72 Ct – Smart Cold Sore Patch – Soothe Itching, Burning

The Duo cold sore patches are a must-have for anyone who experiences painful cold sores. This package includes two types of patches: the original thin patch for daytime use and a larger, thicker patch for nighttime use.

One of the primary benefits of using these patches is their ability to soothe painful itching and burning associated with cold sores. The patch provides a protective layer over the affected area, which helps to alleviate irritation and discomfort.

The SMART Cold Sore Original patch is ultra-thin, with tapered edges, and measures 12mm in diameter. This makes it perfect for daytime use, as it is virtually invisible on the skin. The package includes 36 of these patches, ensuring you have enough to last you through multiple outbreaks.

The SMART Cold Sore Large patch is thicker, measuring 15mm in diameter, and is ideal for nighttime use. The larger size provides extra coverage and protection while you sleep, allowing your skin to heal more effectively. Like the original patch, the package includes 36 of these patches.

3. Lavender Lysine Fast Relief Soothing Gel.

Introducing the Urban ReLeaf L-Lysine Blister Soothing Gel with Lavender Oil – the perfect solution for those seeking fast and effective relief from cold sores, fever spots, rashes, red bumps, pox, raw and chapped skin. This gentle and soothing gel is designed to provide fast and natural relief while helping to suppress future outbreaks and heal delicate tissue.

With its daily use formula, the Urban ReLeaf L-Lysine Blister Soothing Gel is perfect for keeping your skin looking its best. The topical application of L-Lysine has been proven to suppress future outbreaks with regular use, while Lavender Essential Oil provides an extremely soothing effect on the skin. The gel is 100% natural and does not sting, burn or tingle, making it ideal for those with delicate skin.

The Urban ReLeaf L-Lysine Blister Soothing Gel uses USP grade L-Lysine HCL, an essential amino acid that your body needs to prevent outbreaks and repair tissue. Since your body cannot produce Lysine on its own, topical application of this essential amino acid 'works like magic' to prevent cold sores. The unique formula of this gel provides cells with the L-Lysine amino acid building blocks they need to heal and keep tissues strong.

This "most gentle formula" comes in a handy 1.2 ounce bottle, making it easy to carry in your pocket, purse, bedside, or desk for when you need it. The Urban ReLeaf L-Lysine Blister Soothing Gel is a drug-free alternative and proudly made in the USA in small batches.

4. Quick Relief: Herplex Tablets For Cold Sores

Introducing Herplex Cold Sore Tablets, the non-prescription, homeopathic aid that helps reduce the symptoms of cold sore outbreaks. These 60-count rapid relief tablets are a safe, over-the-counter alternative to L-Lysine capsules, Lysine ointments, and prescription products.

The patented formula combines carefully selected ingredients that work with your body, not on it, to help stop breakouts. Anantherum Muricatum 12x, Clematis Erecta 12x, Mezereum 12x, Phytolacca Decandra 12x, Ranunculus Bulbosus 12x, Rhus Toxicodendron 12x, Thuja Occidentalis 12x, Natrum Muriaticum 30x, and Sepia 30x are the active ingredients that make up the formula. The tablets are manufactured in the USA in a GMP certified facility for your peace of mind.

Stress and lack of sunlight can cause your interferon levels to drop. Interferon is the antibody your body produces to keep sores in check, so this drop can exacerbate symptoms. Getting your interferon levels back up is crucial, and Herplex Cold Sore Tablets work with your body to ease symptoms quickly and with no side effects.

The tablets are small and easy to swallow, mess-free, and easier to use than ointments. Simply begin taking the tablets as needed, and rest easy knowing there are no side effects to worry about.

If you're looking for an effective and safe way to reduce the symptoms of cold sore outbreaks, look no further than Herplex Cold Sore Tablets. Try them today and experience the difference for yourself.

5. Red Light Relief For Oral Sores

Introducing the zobosin – a revolutionary light therapy device that offers advanced treatment for oral and lip blisters. The device is equipped with both a red chip and a NIR chip, which work together to deliver optimized wavelengths and irradiance. Studies have shown that these two wavelengths are more effective when used in combination, resulting in faster and more efficient skin rejuvenation.

One of the unique features of the zobosin is its direct light output design. Unlike other devices that use a light guide tube, the zobosin's direct light output design ensures that the light is delivered directly to the skin tissue without any loss of intensity. This means that the light therapy treatment is more powerful and effective, resulting in better skin rejuvenation.

The zobosin is a game-changer in the field of oral and lip blister treatment. It is a non-drug, non-invasive therapy that is easy to use. The device is equipped with a built-in battery, which means that it can be used without having to constantly plug it into a charger. This makes it a convenient and portable option for those who are on-the-go.

Before using the zobosin, it is recommended that users read the product manual in detail and follow the instructions carefully. With its clinically-optimized wavelength and irradiance, the zobosin is a safe and effective way to rejuvenate skin tissue and treat oral and lip blisters. Try the zobosin today and experience the benefits of advanced light therapy technology.

6. Cold Sore Care: Faster Symptom Relief

Introducing NextLeap, a unique gel formula designed to reduce the visible impact of cold sores or fever blisters caused by herpes outbreaks. Based on surveys of over 4,000 cold sore sufferers, 85% of them reported wanting a better solution than their current treatment. NextLeap has answered that call by providing a cosmetic approach to cold sore care.

With Tranexamic Acid as its main ingredient, NextLeap has been shown to consistently resolve the appearance of a herpes outbreak within 24-48 hours if used at symptom onset. This results-oriented formula is not a cover-up for cold sores, but a clear serum that quickly addresses the visual impact of the outbreak.

If applied at the first tingle, NextLeap can prevent the outbreak from becoming visible. However, if the sore is already visible, NextLeap still provides helpful benefits. It is focused on resolving the problem fast so that you don’t need a cover-up.

NextLeap works well by itself, but it can also be used in combination with other topical cold sore products such as Abreva. When used together, they work in different ways, providing even faster results.

In addition to fighting cold sores, NextLeap is also effective against redness from various sources such as spider veins, sunburn, rosacea, and the redness remaining after healing from cuts, scrapes, or medical procedures. It also works well against dark spots or melasma.

Typical dark spot correctors can take up to 3 months for full benefits. Using NextLeap underneath a dark spot corrector or an exfoliation product may give faster results.

For best results, squeeze a drop of NextLeap at a time and apply it thoroughly to the affected area with a clean cotton swab or your finger. Wash your hands before and after use. When used alone, apply 3-4 times daily for cold sores until full resolution, and morning and night for other skin discoloration until satisfied with your appearance. When used underneath another product or herpes medications, follow frequency instructions for that product.

Each tube of NextLeap contains 4g of the gel formula. The tube could contain 7g, but it is intentionally designed to allow for safe shipping. 4g volume equals 2 tubes of Abreva, for example, and can treat multiple outbreaks.

7. Abreva Abreva Cold Sore/fever Blister Treatment, 2 Gms (Pack Of 2)

If you're someone who struggles with cold sores or fever blisters on your face or lips, then the [Product Name] may be just what you need. This innovative treatment is specifically designed to target such sores and blisters, providing you with quick and effective relief.

One of the key benefits of this product is its fast-acting formula. With the [Product Name], you can expect to see results in a matter of hours rather than days. This is because the formula is designed to penetrate deep into the affected area, providing rapid relief from pain and discomfort.

Another key advantage of this product is its ease of use. The [Product Name] comes in a convenient applicator that makes it easy to apply the formula directly to the affected area. This means you can get relief without having to mess around with messy creams or ointments.

In addition to its fast-acting formula and easy-to-use applicator, the [Product Name] is also backed by rigorous scientific research. This product has been clinically tested to ensure its effectiveness, so you can rest assured that you're using a product that has been proven to work.

8. Aidance Terragen Hg Formula Max – Natural Gentle Cream For Herpes Sufferers – 14gm Tube

The Terragen HG Formula MAX is a highly effective treatment for herpes sores, painful eruptions, and aggravated skin. It features Aidance's patented Activated Minerals blend, which contains therapeutic properties that help soothe and heal the skin. This product has been carefully formulated to ensure that it is free of unnecessary chemicals, artificial scents, parabens, and potentially harmful preservatives.

What sets Terragen HG Formula MAX apart from other treatments is its deep moisturizing formula. This unique blend is paraben-free, alcohol-free, dye-free, and fragrance-free, making it non-irritating and safe for even the most sensitive skin. The formula is designed to penetrate deep into the skin, providing long-lasting relief from discomfort and pain.

One of the key benefits of Terragen HG Formula MAX is its patented Activated Minerals blend. This blend contains a unique combination of minerals that work together to promote healing and soothe irritated skin. Unlike other treatments, this formula is non-greasy and absorbs quickly into the skin, providing fast relief from discomfort and pain.

In addition to its therapeutic benefits, Terragen HG Formula MAX is also incredibly easy to use. Simply apply a small amount of the formula to the affected area and let it absorb into the skin. The formula can be used as often as needed to provide relief from discomfort and pain.

9. Lip Clear Lysine+ Cold Sore Treatment 0.25 Oz

Quantum LipClear Lysine Plus Cold Sore Ointment is a highly effective and fast-acting product that helps to relieve the symptoms of cold sores. This ointment is a natural alternative to traditional medications, as it contains a combination of active ingredients that work together to soothe, moisturize, and protect the affected area.

One of the key ingredients in this ointment is Lysine, an essential amino acid that is known to support the immune system and help prevent the spread of cold sores. This powerful amino acid works by inhibiting the growth of the virus that causes cold sores, which can help to reduce the frequency and severity of outbreaks.

In addition to Lysine, Quantum LipClear Lysine Plus Cold Sore Ointment also contains a blend of natural herbs and vitamins that work together to promote healing and relieve discomfort. These ingredients include Zinc Oxide, Menthol, Calendula Officinalis, and Echinacea Purpurea, all of which are known for their anti-inflammatory and antiviral properties.

This ointment is easy to apply, with a smooth and creamy texture that glides on smoothly and absorbs quickly into the skin. It can be used both during the onset of a cold sore outbreak, as well as throughout the healing process, to provide maximum relief and protection.

10. Releev 1 Day Cold Sore Treatment 6ml

The product being reviewed is an effective solution for treating cold sores and fever blisters. The formula is designed to not only alleviate the symptoms of pain, tingling, itching, and burning, but also to soothe the affected area without causing any irritation.

With its patented Viracea formula, this product is a reliable option for those suffering from cold sores or fever blisters. It contains active ingredients that work together to address the root cause of the problem and provide relief from discomfort.

Unlike other products on the market which can be harsh and irritating to the skin, this one is gentle and non-irritating. It is designed to be applied directly to the affected area, providing fast and effective relief that can be felt almost immediately.

In addition to its effectiveness, this product is also easy to use, making it an ideal choice for those who lead busy lives. It comes in a convenient tube that is easy to carry with you wherever you go, so you can always have it on hand when you need it.

Best Cold Sore Medicine Prescription FAQs

Are prescription cold sore medicines safe for long-term use?

Prescription cold sore medicines are safe for long-term use if they are taken under the supervision of a healthcare professional. These medicines are designed to reduce the severity and frequency of cold sore outbreaks, and they are generally well-tolerated by most people. However, like any medication, there are risks associated with long-term use, including the potential for side effects and the development of drug resistance.

It is important to follow the instructions provided by your healthcare provider and to report any side effects or concerns that you may have about the medication. Your healthcare provider may also periodically review your treatment plan to ensure that it is still appropriate for your needs.

In addition to prescription medications, there are also several over-the-counter remedies that can help alleviate the symptoms of cold sores. These remedies include topical creams, ointments, and gels that can help reduce pain, itching, and inflammation.

If you are experiencing frequent cold sore outbreaks, it is important to speak with your healthcare provider to determine the best course of treatment for your individual needs.

Are there any prescription cold sore medicines specifically designed for children or pregnant women?

Yes, there are prescription cold sore medicines that are specifically designed for children and pregnant women. Cold sores are caused by the herpes simplex virus and can be treated with antiviral medications. Acyclovir is an antiviral medication that is often prescribed for cold sores. It is considered safe for use in children and pregnant women when prescribed by a healthcare provider.

Another antiviral medication used to treat cold sores is Penciclovir. This medication is available as a cream and is approved for use in children aged 12 and above. However, there is limited data available on the safety of Penciclovir in pregnant women.

It is important to consult with a healthcare provider before taking any medication during pregnancy or giving it to a child. Additionally, over-the-counter creams and ointments should be avoided as they may contain ingredients that are not safe for pregnant women or children.

Can prescription cold sore medicines be used in conjunction with other treatments?

Prescription cold sore medicines can be used in conjunction with other treatments, but it is important to consult with a healthcare professional before doing so. Some common treatments for cold sores include antiviral medications, topical creams, and pain relievers. Antiviral medications, such as acyclovir, famciclovir, and valacyclovir, can help to reduce the severity and duration of cold sore outbreaks. Topical creams, such as docosanol or penciclovir, can also help to reduce symptoms and promote healing. Pain relievers, such as ibuprofen or acetaminophen, can help to alleviate discomfort associated with cold sores. However, it is important to note that combining different treatments may increase the risk of side effects or interactions. Therefore, it is important to follow the advice of a healthcare professional and use medications as directed.

Can prescription cold sore medicines prevent future outbreaks?

Prescription cold sore medicines can help to reduce the frequency of future outbreaks, but they cannot completely prevent them. Antiviral medications such as acyclovir, famciclovir, and valacyclovir work by inhibiting the replication of the virus that causes cold sores, which can reduce the severity and duration of outbreaks. These medications are often prescribed to people who experience frequent or severe cold sores, or who have a weakened immune system.

However, it’s important to note that while these medications can be effective, they are not a cure for cold sores. The virus that causes cold sores (herpes simplex virus) remains in the body even when symptoms are not present, and can still be spread to others through close contact. Therefore, it’s important to continue taking precautions to prevent the spread of the virus, such as avoiding close contact with others during outbreaks, washing hands frequently, and avoiding sharing personal items like towels or utensils.

How do prescription cold sore medicines compare to over-the-counter options?

Prescription cold sore medicines typically contain antiviral drugs such as acyclovir, valacyclovir, or famciclovir. These drugs work by stopping the herpes simplex virus from reproducing, which can help reduce the severity and duration of cold sore outbreaks. Over-the-counter options for cold sores typically contain topical creams or ointments that can help soothe the affected area and reduce pain, but they do not contain antiviral drugs. While over-the-counter options may provide some relief, prescription medications tend to be more effective at treating cold sores. However, prescription medications may also have more potential side effects and may be more expensive than over-the-counter options. It is important to speak with a healthcare provider to determine the best treatment option for individual needs and circumstances. Additionally, it is important to note that while prescription medications can help reduce the frequency and severity of cold sore outbreaks, they cannot cure the herpes simplex virus and outbreaks may still occur.

How often should prescription cold sore medicines be applied?

The frequency of application of prescription cold sore medicines depends on the specific medication prescribed by your healthcare provider. However, most commonly prescribed antiviral medications for cold sores, such as acyclovir, valacyclovir, and famciclovir, are typically used for 5 to 10 days. These medications are usually taken orally, and the dosage may vary depending on the severity of the outbreak and individual factors such as age and overall health.

It is important to follow your healthcare provider's instructions carefully and take the medication as prescribed, even if your symptoms improve before the medication is finished. If you miss a dose, take it as soon as possible, but do not double the dose to make up for the missed one.

It is also important to note that while these medications can help to reduce the duration and severity of cold sore outbreaks, they do not cure the underlying virus. Therefore, it is essential to take steps to prevent future outbreaks, such as avoiding triggers like stress and excessive sun exposure, and practicing good hygiene, such as washing your hands frequently and avoiding touching your face.

How quickly do prescription cold sore medicines work?

Prescription cold sore medicines are designed to work quickly to reduce the duration and severity of cold sores. The effectiveness of these medicines can vary depending on the specific medication and the severity of the outbreak. Generally, prescription cold sore medicines can start working within hours of use. For example, topical creams like acyclovir and penciclovir can begin reducing symptoms and promoting healing within 24 hours of use. Oral medications like valacyclovir and famciclovir can also begin to reduce symptoms within a day and shorten the duration of the outbreak. It's important to note that while these medications can help speed up recovery time, they are most effective when used at the first sign of a cold sore. If left untreated, cold sores can take longer to heal and may cause more discomfort. It's always best to consult with a healthcare provider to determine the most effective treatment plan for your individual needs.

What are the most effective prescription cold sore medicines?

There are several prescription cold sore medicines available in the market that have shown to be effective in treating cold sores. One of the most commonly prescribed medications is Acyclovir, which is available in the form of a topical cream or an oral medication. It works by preventing the herpes virus from replicating, and thus, reduces the duration and severity of cold sores. Valacyclovir is another antiviral medication that is often prescribed for cold sores and can be taken orally.

Another popular option is Penciclovir cream, which is a topical antiviral medication that can help to reduce the duration and symptoms of cold sores. Docosanol is another medication that is available as a topical cream and works by preventing the virus from entering healthy cells.

It is important to note that the effectiveness of these medications may vary from person to person, and some people may experience side effects such as headaches, nausea, and diarrhea. Therefore, it is essential to consult with a healthcare professional before using any prescription medication for cold sores.

What are the potential side effects of prescription cold sore medicines?

Prescription cold sore medicines are antiviral drugs that are used to treat outbreaks of cold sores. While these drugs are generally safe and effective, they can cause some side effects. The most common side effects of prescription cold sore medicines include headaches, nausea, vomiting, and diarrhea. Some people may also experience dizziness, fatigue, or abdominal pain.

In rare cases, prescription cold sore medicines can cause more serious side effects, such as allergic reactions, hives, or difficulty breathing. If you experience any of these symptoms, you should seek medical attention immediately.

It is important to note that prescription cold sore medicines are not recommended for everyone. They may interact with other medications you are taking or exacerbate underlying health conditions. Your healthcare provider can help you determine whether a prescription cold sore medicine is right for you, and monitor you for potential side effects.

What factors should be considered when choosing a prescription cold sore medicine?

When choosing a prescription cold sore medicine, there are several factors that should be considered to ensure effectiveness and safety. Firstly, it is important to consult with a healthcare provider to determine the severity and frequency of your cold sores, as well as any underlying health conditions or medications that may interact with the medicine.

Secondly, the active ingredients in the medicine should be evaluated. Antiviral medications such as acyclovir, famciclovir, and valacyclovir are commonly prescribed for cold sores, but they may have different dosages and methods of administration. It is important to follow the instructions carefully and complete the full course of treatment to achieve the best results.

Thirdly, the potential side effects and risks of the medicine should be weighed against the benefits. Common side effects may include nausea, dizziness, and headache, while more serious adverse reactions such as allergic reactions and kidney damage may occur in rare cases.

Lastly, the cost and insurance coverage of the medicine should also be considered. Some prescription cold sore medicines may be expensive, but there may be generic options or patient assistance programs available to help with the cost.

Overall, choosing a prescription cold sore medicine requires careful consideration of multiple factors to ensure safe and effective treatment.

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