Best Vitamin B12 And Folate Supplements (2025 Update)
If you’re looking for the best vitamin B12 and folate supplements, it’s essential to consider several factors before making a purchase. One of the primary considerations is the potency of the supplements. Look for products that provide high-quality active ingredients with minimal amounts of fillers. Additionally, consider the type of supplement that will best meet your needs; some people may prefer capsules, while others may prefer liquids or gummies.
Another key factor to consider is the potential side effects of any supplements you consider. Although many vitamin B12 and folate supplements are generally safe for most people to use, some individuals may experience side effects like nausea, diarrhea, or headaches. Be sure to read the labeling carefully or consult with a healthcare professional before starting any new supplement regimen.
If you’re unsure about which vitamin B12 and folate supplement is right for you, consider some key questions before making your purchase. For example, do you prefer a vegan or non-vegan supplement? Are you looking for a high-potency product, or would you prefer a lower-potency option? And are you looking for a stand-alone supplement or a multi-vitamin that includes vitamin B12 and folate alongside other essential vitamins and minerals? By considering these and other key factors, you can make an educated decision that best meets your health and wellness needs.
10 Best Vitamin B12 And Folate Supplements
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This product is ideal for supporting cellular energy production, sleep, and brain health through a bioactive form of vitamin B-12.
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The product is ideal for people looking to supplement their diet with Vitamin B12 and Folic Acid in a tasty chewable tablet form.
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Ideal for improving energy, metabolism, and overall health through the consumption of high potency B vitamins and probiotics.
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It is an ideal supplement for supporting mood and energy with its blend of bioactive B vitamins.
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Ideal for boosting energy with 400 mcg of folic acid and 1000 mcg of vitamin B12 per serving. Soy-free, gluten-free, dairy-free, and vegan.
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This product is ideal for supporting cellular energy production, sleep, and brain health through its bioactive vitamin B-12 content.
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The product is ideal for providing support for energy and homocysteine levels with its combination of methylfolate and vitamin B12.
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This product is ideal for promoting healthy nervous system function and cardiovascular health.
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This product is ideal for supporting a healthy nervous system and cardiovascular health with high potency vitamin B12 and folate.
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The product is ideal for promoting healthy brain cell function through its content of Vitamin B12 and Methyl Folate.
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1. Bioactive Cherry Methyl B-12 For Energy & Brain.
Jarrow Formulas Methyl B-12 (methylcobalamin) is a bioactive coenzyme form of vitamin B12 that is designed to support cellular energy function, sleep, mood, and brain health. This clinical-strength supplement is particularly useful for people who may be deficient in vitamin B12, especially vegetarians, vegans, and those over 50.
The biologically active form of vitamin B12, methyl B12, is naturally recognized by the body, which means it is delivered to your cells more effectively to support your body’s natural cellular energy production. This results in better absorption and utilization of the nutrient, allowing for optimal benefits.
Each cherry-flavored chewable tablet contains 5000 micrograms (mcg) of methyl B-12, making it both convenient and effective. The supplement is free from wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts, or sesame, making it an excellent choice for people with dietary restrictions.
Jarrow Formulas is a brand that is informed by strong scientific research, and their products are carefully crafted to ensure that you get the benefit of each and every vitamin, mineral, and supplement. This means that the Methyl B-12 supplement is designed to provide superior support to your body.
The supplement promotes healthy homocysteine levels, which is essential for cardiovascular health. Additionally, it provides neurotransmitter and neuron support, which is important for maintaining healthy brain function.
2. Creamy Raspberry B12 & Folic Acid Chewables
This product is an excellent dietary supplement that provides essential nutrients to support overall health and wellbeing. It contains 400 mcg of Folate (as Folic Acid) and 1000 mcg of Vitamin B12 per serving, which are both crucial for maintaining healthy brain function, boosting energy levels, and supporting cardiovascular health.
One of the best things about this product is that it is free of yeast, gluten, barley, rice, and sodium. It is also free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, and soybeans, making it ideal for people with dietary restrictions or allergies.
Additionally, this product is carefully handled and shipped by Amazon, in accordance with the manufacturer's recommendations, to ensure that it arrives fresh and effective. So, even during the warm summer months, you can trust that you are getting a quality product.
3. Raw B Complex – Vegan Energy Formula
This high potency B Complex vitamin supplement is ideal for both men and women. It contains a blend of Raw Organic fruits and vegetables, raw probiotics, and enzymes to support energy, metabolism, and immune system health, as well as a healthy response to stress.
The supplement is an excellent source of 8 whole food complexed B vitamins, including thiamin (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), B6, biotin (B7), folate (B9, no synthetic folic acid), and B12 (as Methylcobalamin). These high potencies of B vitamins help support mental and physical energy.
In addition, this B Complex vitamin supplement is great for heart and blood health, containing 133 mcg of vitamin B-12 (5542% DV), 450 mcg DFE of folate (113% DV), and 10mg of vitamin B6 (588% DV), along with 325 mcg of biotin (1083% DV), fruits, and veggies.
To support healthy digestion, this supplement also features raw Lactobacillus probiotics and digestive enzymes Lipase, Protease, Bromelain, Lactase, Papain, and more. Adults can take 2 capsules daily, or they can open the capsules and mix the contents with water or juice.
This B Complex vitamin supplement is Third Party Certified Non GMO, Gluten Free, and Kosher. It is RAW, meaning that there is no high heat, synthetic binders, fillers, artificial flavors, sweeteners, colors, or additives commonly found in tablets. So, one can say yes to clean supplements with confidence.
4. Mood-Boosting B Complex – Vegan Capsules
This B complex vitamin supplement offers superior absorption due to its pre-activated B vitamins in their coenzymated forms, which are readily available for the body to use. This premium blend includes Quatrefolic folate, known for its high bioavailability, solubility, and long-lasting stability, along with all eight vitamins that form the B complex.
In addition, this supplement contains high potency energy support nutrients such as Trimethylglycine TMG and choline supplements that support methylation, which can enhance the bioavailability of vitamin B nutrients. B complex vitamins also play a crucial role in supporting mood, energy production, and cardiovascular health.
This supplement is vegan and non-GMO, making it ideal for both women and men who prefer vegetarian and vegan-friendly products. It is also made without GMOs, gluten, dairy, or soy, and the tinted glass bottles provide a barrier against moisture and oxygen, which helps protect nutrient viability.
Trusted by over 50,000 doctors, Designs for Health has been the physician's choice for top-quality professional strength Vit B complex vitamins since 1989. Their "Science First" philosophy ensures their products are based on the most recent research and use only the highest quality raw ingredients.
5. Energetic Essentials: Liquid B12 & Folic Acid
Introducing the raspberry flavored liquid drops that are specially formulated to provide an energy boost to the body! These drops pack a punch with 400 mcg of Folic Acid and 1000 mcg of Vitamin B12 in every serving.
The 2 fl oz liquid drops come with 59 servings, making it easy and convenient to add to your daily routine. The soy-free, gluten-free, dairy-free, and vegan formula is perfect for those with dietary restrictions. Additionally, the product is free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, yeast, gluten, barley, and rice.
These liquid drops are designed to support cellular energy production and overall health. Whether you're looking to improve your daily energy levels or maintain your overall health, this product is perfect for you.
Please note that during the summer months, the product may arrive warm due to shipping. However, Amazon stores and ships products in accordance with manufacturers' recommendations, ensuring that the product you receive is of the highest quality.
Try these raspberry flavored liquid drops today and experience the benefits of cellular energy boost for yourself!
6. Boost B-12 Lemon Tablets For Brain & Energy
Jarrow Formulas Methyl B-12 (methylcobalamin) is a bioactive coenzyme form of vitamin B12 that provides a wide range of health benefits. This biologically active form of vitamin B12 is known to support cellular energy function, sleep, mood, and brain health.
Clinical studies have shown that methyl B12 supplementation can be particularly useful for individuals who are deficient in vitamin B12, especially vegetarians, vegans, and people over 50.
One of the key benefits of Methyl B-12 is that it is naturally recognized by the body. This means that your cells can more effectively absorb and utilize it to support your body's natural cellular energy production.
These lemon-flavored chewable tablets are a convenient way to supplement your diet with this essential nutrient. Each tablet delivers 1000 micrograms (mcg) of methyl B-12 and contains no wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts, or sesame.
Jarrow Formulas is a trusted brand that is committed to delivering superior science and smarter formulas. Their products are carefully crafted based on strong scientific research to ensure that you get the maximum benefit from each and every vitamin, mineral, and supplement.
If you are looking for a high-quality methyl B-12 supplement to support your health and well-being, Jarrow Formulas Methyl B-12 is a great option to consider. Whether you are a vegetarian, vegan, or just looking for a convenient way to supplement your diet, this product is a great choice.
7. Energy+homocysteine Support: Ultra B12-Folate Capsules
The Folate & B12 supplement by Designs for Health is a powerful blend that works together to promote methylation and balanced concentrations of homocysteine. This product is ideal for vegans and vegetarians, providing a safe and effective way to support their nutritional needs.
One of the key features of this supplement is its proprietary NatureFolate blend, which contains safe and naturally-occurring folates in their active 5-MTHF form. This ensures that the body can easily absorb and utilize the folate content in the supplement.
In addition to folate, the premium B12 in this product comes from equal amounts of adenosylcobalamin and methylcobalamin, providing an active and effective form of B12. Each capsule contains 2000 mg of this powerful blend.
Designs for Health is committed to maintaining a strict, no-compromises approach to quality raw material selection. This product is Non-GMO, Gluten-Free, and Vegetarian-friendly, ensuring that it is suitable for a wide range of dietary needs.
It is important to note that over 50,000 doctors agree that Designs for Health is the physician's choice for top quality professional strength supplements since 1989. This is due to their "Science First" philosophy, which ensures that their products are based on the most recent research and use the highest quality raw ingredients.
8. Nerve & Heart Boost: Intrinsi-B12 Folate
This product is a non-GMO and gluten-free dietary supplement that provides 20 mg intrinsic factor. It is designed to support the healthy function of the cardiovascular and nervous systems.
The product is rich in vitamin B12 and folate, both of which are essential for the synthesis of DNA and the proper growth and function of cells throughout the body.
To enhance the absorption of vitamin B12, the product contains porcine-derived intrinsic factor, a natural glycoprotein. This unique ingredient helps to ensure that the body can effectively utilize the vitamin B12 in the supplement.
The manufacturer, Metagenics, Inc., is so confident in the quality and effectiveness of this product that it is covered by their 60-Day Satisfaction Guarantee. Additional terms and conditions apply, which can be found below.
This supplement is an excellent choice for anyone looking to support their overall health and well-being through proper nutrition. With its high levels of vitamin B12 and folate, this product is an ideal addition to any daily supplement regimen.
9. High Potency B12 For Nervous & Cardio Health
This product is a Non-GMO and gluten-free dietary supplement that contains high levels of vitamin B12 and folate, combined with intrinsic factor to improve absorption and assimilation. Each tablet of this supplement contains 500 mcg of vitamin B12, 1,330 mcg DFE of folate, and 20 mg of intrinsic factor.
This supplement is designed to support healthy cardiovascular and nervous system function. Vitamin B12 is essential for the proper functioning of the nervous system, while folate aids in the production of red blood cells and helps maintain healthy homocysteine levels. The intrinsic factor in this supplement is a natural glycoprotein that may enhance the absorption of vitamin B12.
This supplement is manufactured by Metagenics, Inc. and is covered by their 60-Day Satisfaction Guarantee. Additional terms apply, and details can be found below.
This product is a great option for individuals who are looking for a high-quality supplement to support their cardiovascular and nervous system health. It is also a good choice for those who are looking for a Non-GMO and gluten-free option.
10. Brain Boost B12+folate – Veggie Capsules (8 Words)
The gastrointestinal tract and nervous system are two vital parts of the body, and Vitamin B12 and Folate play a crucial role in supporting their health. This supplement combines the power of these two essential vitamins to provide optimal support for the GI tract and nerves.
The formula contains methylated forms of B12 and Folate, which are considered to be the most bioavailable. This means that they are easily absorbed and utilized by the body, ensuring maximum effectiveness. The supplement is also free from coatings and binders, gluten, dairy, soy, and sugar, making it suitable for a wide range of dietary needs.
For pregnant women, the supplement is particularly beneficial, as it provides 800mcg of Folate as L-5-MTHF. This form of Folate is highly bioavailable and may reduce the risk of neural tube birth defects, making it a valuable addition to any prenatal vitamin regimen.
Quality, purity, and potency are of utmost importance to Vital Nutrients, the makers of this supplement. They are committed to providing high-quality supplements that support health and vitality. With this supplement, you can trust that you are getting a product that is safe, effective, and backed by rigorous quality standards.
Best Vitamin B12 And Folate Supplements FAQs
Are there any benefits to taking a combination supplement of vitamin B12 and folate?
Yes, taking a combination supplement of vitamin B12 and folate can provide numerous health benefits. Vitamin B12 and folate are both essential nutrients that the body needs to function properly. Vitamin B12 helps in the formation of red blood cells, DNA synthesis, and nerve function, while folate is important for cell growth and division, DNA synthesis, and the prevention of birth defects.
When taken together, vitamin B12 and folate work synergistically to support healthy brain function, improve energy levels, and boost immune system function. In addition, this combination supplement has been shown to help reduce the risk of heart disease, stroke, and certain types of cancer.
Furthermore, many people are deficient in vitamin B12 and folate, especially vegetarians and vegans who may not get enough of these nutrients from their diet. Therefore, taking a combination supplement of vitamin B12 and folate can help to ensure that these essential nutrients are present in the body in the right amount.
Are there any natural sources of vitamin B12 and folate that I should consider?
Vitamin B12 and folate are essential nutrients that play a crucial role in maintaining good health. Although these nutrients are mostly found in animal-based foods, there are some natural sources of vitamin B12 and folate that vegans and vegetarians can consider. For vitamin B12, fortified cereals, plant-based milks, and nutritional yeast are good options. Additionally, some types of seaweed like nori and spirulina contain vitamin B12, but the amount may vary depending on the brand and preparation method. As for folate, leafy greens like spinach, kale, and collard greens are excellent sources. Other plant-based sources of folate include asparagus, broccoli, and legumes like lentils and chickpeas. However, it is important to note that natural sources of these nutrients may not provide enough to meet daily requirements, especially for those with limited diets. In such cases, supplements may be necessary to ensure adequate intake.
Are there any side effects associated with taking vitamin B12 and folate supplements?
Vitamin B12 and folate supplements are generally safe and well-tolerated when taken as directed. However, like any supplement or medication, there can be potential side effects.
Common side effects of taking vitamin B12 supplements include diarrhea, nausea, and stomach upset. These symptoms usually go away on their own within a few days of starting the supplement. In rare cases, high doses of vitamin B12 may cause more serious side effects, such as nerve damage.
Folate supplements may also cause minor side effects, such as nausea, loss of appetite, and bloating. However, these side effects generally go away as the body adjusts to the supplement. High doses of folate may mask the symptoms of vitamin B12 deficiency, which can lead to nerve damage if left untreated.
It is important to talk to your healthcare provider before taking any supplements, especially if you have a medical condition or are taking other medications. They can help you determine if vitamin B12 or folate supplements are right for you and what dosage is safe for your individual needs.
Are there any specific health conditions or dietary restrictions that require higher levels of vitamin B12 and folate supplementation?
Yes, there are certain health conditions and dietary restrictions that require higher levels of vitamin B12 and folate supplementation. Vegetarians and vegans are at risk of deficiency in vitamin B12 as it is mainly found in animal-based foods. In such cases, vitamin B12 supplements are recommended. Similarly, individuals with malabsorption issues, such as those with celiac disease or Crohn's disease, may require higher levels of vitamin B12 supplementation as their bodies may not absorb it properly from food.
Pregnant women also require higher levels of folate supplementation to prevent birth defects in their babies. This is because folate plays a crucial role in fetal development, particularly in the formation of the neural tube. Women planning to conceive are also advised to take folic acid supplements.
Individuals with pernicious anemia, a condition where the body is unable to produce enough red blood cells due to a lack of vitamin B12, may also require higher levels of vitamin B12 supplementation. Additionally, elderly individuals may require higher levels of vitamin B12 and folate as their bodies may not absorb these vitamins as efficiently as younger individuals. It is always advisable to consult a healthcare professional before starting any vitamin supplementation.
Can vitamin B12 and folate supplements help with energy levels and fatigue?
Yes, vitamin B12 and folate supplements can help with energy levels and fatigue. Both of these vitamins play a crucial role in the production of red blood cells, which are responsible for carrying oxygen throughout the body. When there is a deficiency of either vitamin, it can lead to anemia, which can cause fatigue, weakness, and shortness of breath.
Vitamin B12 is found in animal-based foods, and folate is found in leafy green vegetables, legumes, and fortified cereals. However, some individuals may have difficulty absorbing these vitamins from food, or they may not consume enough in their diet. In these cases, supplements can be beneficial in improving energy levels and reducing fatigue.
It's important to note that while supplements can be helpful, they should not be relied upon as a substitute for a healthy diet. It's always best to obtain vitamins and nutrients from a balanced diet whenever possible. If you are experiencing persistent fatigue, it's also important to consult with a healthcare provider to rule out any underlying medical conditions.
How do I choose the right vitamin B12 and folate supplement for my needs?
When choosing a vitamin B12 and folate supplement, it is important to consider your individual needs and factors such as age, diet, and health conditions. Here are some tips to help guide your decision:
1. Look for a supplement that contains the active forms of B12 and folate: Methylcobalamin and methylfolate respectively. These forms are more easily absorbed and utilized by the body.
2. Consider your dosage needs: The recommended daily intake for B12 is 2.4 micrograms and for folate is 400 micrograms. However, some individuals may require higher doses due to deficiencies or certain health conditions.
3. Check for additional ingredients: Some supplements may contain additional ingredients such as fillers, binders, or allergens that may not be suitable for your needs.
4. Choose a reputable brand: Look for brands that have been third-party tested for quality and purity.
5. Consult with a healthcare professional: It is always a good idea to consult with a healthcare professional before starting any new supplement to ensure it is appropriate for your individual needs and to avoid any potential interactions with medications or health conditions.
How long does it take to see results from taking a vitamin B12 and folate supplement?
The time it takes to see results from taking a vitamin B12 and folate supplement varies from person to person. Generally, it can take a few weeks to a few months to notice any significant changes in symptoms related to a deficiency of these vitamins.
If you have been experiencing symptoms of a vitamin B12 or folate deficiency, such as fatigue, weakness, tingling in the hands and feet, or difficulty concentrating, it is important to speak with your healthcare provider. They may recommend starting a supplement regimen or undergoing further testing to determine the underlying cause of your symptoms.
It is important to note that taking too much of these vitamins can also have negative effects on your health, so it is important to follow your healthcare provider's recommendations and not exceed the recommended daily allowance. Additionally, it is important to maintain a balanced diet rich in whole foods to ensure adequate intake of all essential vitamins and minerals.
Is it safe to take vitamin B12 and folate supplements long-term?
Taking vitamin B12 and folate supplements long-term is generally considered safe for most people. Both vitamin B12 and folate are essential nutrients that play important roles in the body, such as supporting the formation of red blood cells, promoting healthy brain function, and maintaining a healthy nervous system.
While it is possible to get these nutrients from a balanced diet that includes foods like meat, fish, eggs, dairy, leafy greens, and whole grains, some people may not get enough through their diet alone. This is particularly true for vegans and vegetarians who may not consume enough vitamin B12 from plant-based sources.
If you are considering taking vitamin B12 and folate supplements, it is important to talk to your healthcare provider first. They can help determine if you have a deficiency and recommend the appropriate dosage for your needs. It is also important to follow the recommended dosage and not exceed it, as high doses of these vitamins can be harmful.
What are the best vitamin B12 and folate supplements on the market?
Choosing the best vitamin B12 and folate supplements can be overwhelming with so many options available in the market. However, there are a few factors that you can consider when making a decision. Firstly, it's important to choose a reputable brand that uses high-quality ingredients and follows good manufacturing practices. Secondly, you may want to consider the dosage and form of the supplement that best suits your needs. Some people prefer sublingual tablets or sprays, while others prefer capsules or gummies.
One of the most popular and well-regarded vitamin B12 supplements is the Jarrow Formulas Methyl B12 supplement. It delivers 5000 mcg of methylcobalamin per serving and is suitable for vegans. Another recommended option is the Solgar Vitamin B12 1000 mcg supplement, which is also suitable for vegetarians and is free from gluten, dairy, and soy.
When it comes to folate supplements, the Thorne Research 5-MTHF supplement is highly recommended. It provides 1000 mcg of 5-MTHF per capsule and is free from gluten, soy, and dairy. Another good option is the Seeking Health Optimal Folate supplement, which contains 1000 mcg of 5-MTHF per capsule and is also suitable for vegans.
Ultimately, when choosing any supplement, it is important to consult with a healthcare professional to ensure that it is safe and appropriate for your individual needs.
What is the recommended dosage for vitamin B12 and folate supplements?
The recommended dosage for vitamin B12 and folate supplements varies depending on age, gender, and other factors such as pregnancy or certain medical conditions. For healthy adults, the recommended daily intake of vitamin B12 is 2.4 micrograms per day, while the recommended daily intake of folate is 400 micrograms per day. Women who are pregnant or planning to become pregnant are advised to take higher doses of folate, up to 600-800 micrograms per day, to reduce the risk of birth defects. Individuals with certain medical conditions, such as pernicious anemia or malabsorption disorders, may require higher doses of vitamin B12 supplements to maintain adequate levels in the body. It is important to consult with a healthcare professional before starting any supplement regimen to determine the appropriate dosage and ensure safe use.
